منابع مشابه
Tied down by shear force: role for Tie1 in postnatal vascular remodeling?
Shear forces play an important role in the regulation of vascular function and structure. Since the initial demonstration of flow-dependent dilation, the critical role of the endothelium in sensing changes in intimal shear stress, and transducing these into changes in vascular tone, has been well recognized.1–3 The moment-to-moment adjustments in arterial diameter involve the release of endothe...
متن کاملDeath DNase tied down
elomeric proteins may have an unexpected connection to the mitotic spindle. On page 819, Xu and Blackburn provide evidence that the human homologue of a yeast telomere-binding protein is found on anaphase midzone microtubules. The telomeric functions of the human and yeast versions of this protein, Rif1, have diverged during evolution. In budding yeast, Rif1 is a telomere-bound negative regulat...
متن کاملIsolation of primary cilia by shear force.
The cell's primary cilium is both a mechanical and chemical sensor involved in many signaling pathways. In order to ascertain protein enrichment in the primary cilium or study sub-ciliary localization of various proteins, it is advantageous to remove the primary cilium from the cell body. The protocol described here gives detailed instructions on purifying primary cilia by separating them from ...
متن کاملTuning fork shear-force feedback.
Investigations have been performed on the dynamics of a distance regulation system based on an oscillating probe at resonance. This was examined at a tuning fork shear-force feedback system, which is used as a distance control mechanism in near-field scanning optical microscopy. In this form of microscopy, a tapered optical fiber is attached to the tuning fork and scanned over the sample surfac...
متن کاملBacterial Adhesion to Target Cells Enhanced by Shear Force
Surface adhesion of bacteria generally occurs in the presence of shear stress, and the lifetime of receptor bonds is expected to be shortened in the presence of external force. However, by using Escherichia coli expressing the lectin-like adhesin FimH and guinea pig erythrocytes in flow chamber experiments, we show that bacterial attachment to target cells switches from loose to firm upon a 10-...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2004
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000119803.07796.ca